Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

S. Desikan, Rahul; Chieh Fan, Chun; Wang, Yunpeng; J. Schork, Andrew; Cabral, Howard; Adrienne Cupples, L.; K. Thompson, Wesley; M. Besser, Lilah; A. Kukull, Walter; Holland, Dominic; Chen, Chi‐Hua; B. Brewer, James; S. Karow, David; Kauppi, Karolina; Witoelar, Aree; M. Karch, Celeste; W. Bonham, Luke; S. Yokoyama, Jennifer; J. Rosen, Howard; L. Miller, Bruce; P. Dillon, William; M. Wilson, David; P. Hess, Christopher; A. Pericak‐Vance, Margaret; L. Haines, Jonathan; A. Farrer, Lindsay; Mayeux, Richard; Hardy, John; Goate, Alison; T. Hyman, Bradley; D. Schellenberg, Gerard; K. McEvoy, Linda; A. Andreassen, Ole; M. Dale, Anders

doi:10.1371/journal.pmed.1002258

Public

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

Published in PLoS Medicine • Mar 21, 2017

Authors:

Rahul S. Desikan

Chun Chieh Fan

Yunpeng Wang

Abstract

BACKGROUND: Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS A...

Subject

Disease

Medicine

Polygenic risk score

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!