Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

Mandai, Michiko; Watanabe, Akira; Kurimoto, Yasuo; Hirami, Yasuhiko; Morinaga, Chikako; Daimon, Takashi; Fujihara, Masashi; Akimaru, Hiroshi; Sakai, Noriko; Shibata, Yumiko; Terada, Motoki; Nomiya, Yui; Tanishima, Shigeki; Nakamura, Masahiro; Kamao, Hiroyuki; Sugita, Sunao; Onishi, Akishi; Ito, Tomoko; Fujita, Kanako; Kawamata, Shin; J. Go, Masahiro; Shinohara, Chikara; Hata, Ken‐ichiro; Sawada, Masanori; Yamamoto, Midori; Ohta, Sachiko; Ohara, Yasuo; Yoshida, Kenichi; Kuwahara, Junko; Kitano, Yuko; Amano, Naoki; Umekage, Masafumi; Kitaoka, Fumiyo; Tanaka, Azusa; Okada, Chihiro; Takasu, Naoko; Ogawa, Seishi; Yamanaka, Shinya; Takahashi, Masayo

doi:10.1056/nejmoa1608368

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Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

Published in New England Journal of Medicine • Mar 15, 2017

Authors:

Michiko Mandai

Akira Watanabe

Yasuo Kurimoto

Abstract

We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration. The iPSCs were generated from skin fibroblasts obtained from two patients with adv...

Subject

Macular degeneration

Medicine

Induced pluripotent stem cell

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