DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

R. Barr, Alexis; J. Cooper, Samuel; S. Heldt, Frank; Butera, Francesca; Stoy, Henriette; Mansfeld, Jörg; Novák, Béla; Bakal, Chris

doi:10.1038/ncomms14728

Public

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Published in Nature Communications • Mar 20, 2017

Authors:

Alexis R. Barr

Samuel J. Cooper

Frank S. Heldt

Abstract

Abstract Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. ...

Subject

DNA damage

Genome instability

Cell biology

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