Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.

Chaib, Imane; Karachaliou, Niki; Pilotto, Sara; Codony Servat, Jordi; Cai, Xueting; Li, Xuefei; Drozdowskyj, Ana; Codony Servat, Carles; Yang, Jie; Hu, Chunping; Felipe Cardona, Andres; Lopez Vivanco, Guillermo; Vergnenegre, Alain; Miguel Sanchez, Jose; Provencio, Mariano; de Marinis, Filipo; Passaro, Antonio; Carcereny, Enric; Reguart, Noemi; Garcia Campelo, Charo; Teixido, Christina; Sperduti, Isabella; Rodriguez, Sonia; Lazzari, Chiara; Verlicchi, Alberto; de Aguirre, Itziar; Queralt, Cristina; Wei, Jia; Estrada, Roger; Puig de la Bellacasa, Raimon; Luis Ramirez, Jose; Jacobson, Kirstine; J Ditzel, Henrik; Santarpia, Mariacarmela; Viteri, Santiago; Angel Molina, Migual; Zhou, Caicun; Cao, Peng; C Ma, Patrick; G Bivona, Trever; Rosell, Rafael

doi:10.1093/jnci/djx014

Public

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.

Shared by NobleBlocks on Sep 1, 2017 • 12:00 AM UTC

Authors:

Imane Chaib

Niki Karachaliou

Sara Pilotto

Abstract

Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and...

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