Exosomes derived from miR‐181‐5p‐modified adipose‐derived mesenchymal stem cells prevent liver fibrosis <i>via</i> autophagy activation

Qu, Ying; Zhang, Qidi; Cai, Xiaobo; Li, Fei; Ma, Zhenzeng; Xu, Mingyi; Lu, Lungen

doi:10.1111/jcmm.13170

Public

Exosomes derived from miR‐181‐5p‐modified adipose‐derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

Published in Journal of Cellular and Molecular Medicine • Apr 6, 2017

Authors:

Ying Qu

Qidi Zhang

Xiaobo Cai

Abstract

Proliferating hepatic stellate cells (HSCs) respond to liver damage by secreting collagens that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated. Advancement of microRNA (miRNA) hepatic therapies has been hampered by difficulties in delivering miRNA to damaged tiss...

Subject

Microvesicles

Mesenchymal stem cell

Autophagy

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