Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Verstraete, Kenneth; Peelman, Frank; Braun, Harald; M. Lopez, Juan; Van Rompaey, Dries; Dansercoer, Ann; Vandenberghe, Isabel; Pauwels, Kris; Tavernier, Jan; N. Lambrecht, Bart; Hammad, Hamida; De Winter, Hans; Beyaert, Rudi; Lippens, Guy; N. Savvides, Savvas

doi:10.1038/ncomms14937

Public

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Published in Nature Communications • Apr 3, 2017

Authors:

Kenneth Verstraete

Frank Peelman

Harald Braun

Abstract

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a clinical target against asthma calls for maxi...

Subject

Thymic stromal lymphopoietin

Cytokine

Immunology

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