Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide

S. Antonarakis, Emmanuel; Lu, Changxue; Luber, Brandon; Wang, Hao; Chen, Yan; Zhu, Yezi; L. Silberstein, John; N. Taylor, Maritza; L. Maughan, Benjamin; R. Denmeade, Samuel; J. Pienta, Kenneth; J. Paller, Channing; A. Carducci, Michael; A. Eisenberger, Mario; Luo, Jun

doi:10.1200/jco.2016.70.1961

Public

Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide

Published in Journal of Clinical Oncology • Apr 6, 2017

Authors:

Emmanuel S. Antonarakis

Changxue Lu

Brandon Luber

Abstract

Purpose We reported previously that the detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumor cells (CTCs) correlated with poor outcomes from the use of abiraterone and enzalutamide in patients with castration-resistant prostate cancer (CRPC). Here, we expanded our cohort...

Subject

Enzalutamide

Medicine

Prostate cancer

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