Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

Mehrotra, Shikhar; D. Britten, Carolyn; Chin, Steve; Garrett‐Mayer, Elizabeth; Cloud, Colleen; Li, Mingli; Scurti, Gina; L. Salem, Mohamed; H. Nelson, Michelle; B. Thomas, Melanie; M. Paulos, Chrystal; Μ. Salazar, Andres; I. Nishimura, Michael; P. Rubinstein, Mark; Li, Zihai; J. Cole, David

doi:10.1186/s13045-017-0459-2

Public

Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

Published in Journal of Hematology & Oncology • Apr 7, 2017

Authors:

Shikhar Mehrotra

Carolyn D. Britten

Steve Chin

Abstract

BACKGROUND: Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, in conjunction with toll-like receptor (TLR)-3 agonist poly-ICLC, is a promising approach for harnessing immunity against metastatic or locally adv...

Subject

Medicine

Immunotherapy

Internal medicine

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