Clinical, Biochemical, and Genetic Features of 41 Han Chinese Families With Primary Hypertrophic Osteoarthropathy, and Their Therapeutic Response to Etoricoxib: Results From a Six-Month Prospective Clinical Intervention

Li, Shan-Shan; He, Jin-We; Fu, Wen-Zhen; Liu, Yu-Juan; Hu, Yun-Qiu; Zhang, Zhen-Lin

doi:10.1002/jbmr.3157

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Clinical, Biochemical, and Genetic Features of 41 Han Chinese Families With Primary Hypertrophic Osteoarthropathy, and Their Therapeutic Response to Etoricoxib: Results From a Six-Month Prospective Clinical Intervention

Shared by NobleBlocks on Apr 20, 2017 • 12:00 AM UTC

Authors:

Shan-Shan Li

Jin-We He

Wen-Zhen Fu

Abstract

ABSTRACT Primary hypertrophic osteoarthropathy (PHO) is a rare inherited disease caused by genetic defects in the prostaglandin metabolism pathway; disturbed prostaglandin E2 (PGE2) catabolism resulting in increased PGE2 level is suggested in the pathogenesis. Forty-three Han Chinese patients with P...

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