Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

C. Sharp, Gemma; A. Salas, Lucas; Monnereau, Claire; Allard, Catherine; Yousefi, Paul; M. Everson, Todd; Bohlin, Jon; Xu, Zongli; Huang, Rae‐Chi; E. Reese, Sarah; Xu, Cheng‐Jian; Baïz, Nour; Hoyo, Cathrine; Agha, Golareh; Roy, Ritu; W. Holloway, John; Ghantous, Akram; Kebede Merid, Simon; M. Bakulski, Kelly; K. Küpers, Leanne; Zhang, Hongmei; C. Richmond, Rebecca; M. Page, Christian; Duijts, Liesbeth; T. Lie, Rolv; E. Melton, Phillip; M. Vonk, Judith; A. Nøhr, Ellen; R. Williams-DeVane, ClarLynda; Huen, Karen; L. Rifas‐Shiman, Sheryl; Ruiz-Arenas, Carlos; Gonseth, Semira; I. Rezwan, Faisal; Herceg, Zdenko; Ekström, Sandra; Croen, Lisa; Falahi, Fahimeh; Perron, Patrice; R. Karagas, Margaret; M. Quraishi, Bilal; Suderman, Matthew; C. Magnus, Maria; W. V. Jaddoe, Vincent; A. Taylor, Jack; Anderson, Denise; Zhao, Shanshan; A. Smit, Henriëtte; J. Josey, Michele; Bradman, Asa; Baccarelli, Andrea; Bustamante, Mariona; E. Håberg, Siri; Pershagen, Göran; Hertz‐Picciotto, Irva; J. Newschaffer, Craig; Corpeleijn, Eva; Bouchard, Luigi; A. Lawlor, Debbie; L. Maguire, Rachel; F. Barcellos, Lisa; Davey Smith, George; Eskenazi, Brenda; Karmaus, Wilfried; J. Marsit, Carmen; Hivert, Marie‐France; Snieder, Harold; Daniele Fallin, M.; Melén, Erik; Cheng Munthe‐Kaas, Monica; Hasan Arshad, Syed; L. Wiemels, Joseph; Annesi‐Maesano, Isabella; Vrijheid, Martine; Oken, Emily; Holland, Nina; K. Murphy, Susan; I. A. Sørensen, Thorkild; H. Koppelman, Gerard; P. Newnham, John; J. Wilcox, Allen; Nystad, Wenche; J. London, Stephanie; F. Felix, Janine; L. Relton, Caroline

doi:10.1093/hmg/ddx290

Public

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Published in Human Molecular Genetics • Jul 18, 2017

Authors:

Gemma C. Sharp

Lucas A. Salas

Claire Monnereau

Abstract

Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the associ...

Subject

DNA methylation

Epigenetics

Offspring

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