Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

Zheng, Peiming; Chen, Lei; Yuan, Xiangliang; Luo, Qin; Liu, Yi; Xie, Guohua; Ma, Yanhui; Shen, Lisong

doi:10.1186/s13046-017-0528-y

Public

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

Published in Journal of Experimental & Clinical Cancer Research • Apr 12, 2017

Authors:

Peiming Zheng

Lei Chen

Xiangliang Yuan

Abstract

BACKGROUND: Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates that tumor-associated macrophages (TAMs) play an important role in chemoresista...

Subject

Microvesicles

Cancer research

Cisplatin

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