Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Farge, Thomas; Saland, Estelle; de Toni, Fabienne; Aroua, Nesrine; Hosseini, Mohsen; Perry, Robin; Bosc, Claudie; Sugita, Mayumi; Stuani, Lucille; Fraisse, Marine; Scotland, Sarah; Larrue, Clément; Boutzen, Héléna; Féliu, Virginie; Nicolau-Travers, Marie-Laure; Cassant‐Sourdy, Stéphanie; Broin, Nicolas; David, Marion; Serhan, Nizar; Sarry, Audrey; Tavitian, Suzanne; Kaoma, Tony; Vallar, Laurent; S. Iacovoni, Jason; K. Linares, Laëtitia; Montersino, Camille; Castellano, Rémy; Griessinger, Emmanuel; Collette, Yves; Duchamp, Olivier; Barreira, Yara; Hirsch, Pierre; Palama, Tony; Gales, Lara; Delhommeau, François; Garmy‐Susini, Barbara; Portais, Jean‐Charles; Vergez, François; Selak, Mary; Danet-Desnoyers, Gwenn; Carroll, Martin; Récher, Christian; Sarry, Jean-Emmanuel

doi:10.1158/2159-8290.cd-16-0441

Public

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Published in Cancer Discovery • Apr 17, 2017

Authors:

Thomas Farge

Estelle Saland

Fabienne de Toni

Abstract

Abstract Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in vivo, we developed a clinically relevant chemotherapeutic approach treating patient-derived xenografts (PDX) with cytara...

Subject

Myeloid leukemia

Oxidative phosphorylation

Cancer research

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