Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Villani, Alexandra–Chloé; Satija, Rahul; Reynolds, Gary; Sarkizova, Siranush; Shekhar, Karthik; Fletcher, James; Griesbeck, Morgane; Butler, Andrew; Zheng, Shiwei; Lazo, Suzan; Jardine, Laura; Dixon, David; Stephenson, Emily; Nilsson, Emil; Grundberg, Ida; McDonald, David; Filby, Andrew; Li, Weibo; L. De Jager, Philip; Rozenblatt–Rosen, Orit; A. Lane, Andrew; Haniffa, Muzlifah; Regev, Aviv; Hacohen, Nir

doi:10.1126/science.aah4573

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Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Published in Science • Apr 20, 2017

Authors:

Alexandra–Chloé Villani

Rahul Satija

Gary Reynolds

Abstract

What's in a drop of blood? Blood contains many types of cells, including many immune system components. Immune cells used to be characterized by marker-based assays, but now classification relies on the genes that cells express. Villani et al. used deep sequencing at the single-cell level and unbias...

Subject

Biology

Progenitor cell

Immune system

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