Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson’s disease dementia

Kandiah, Nagaendran; Pai, Ming-Chyi; Senanarong, Vorapun; Looi, Irene; Ampil, Encarnita; Won Park, Kyung; Krishna Karanam, Ananda; Christopher, Stephen

doi:10.2147/cia.s129145

Public

Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson’s disease dementia

Published in Clinical Interventions in Aging • Apr 1, 2017

Authors:

Nagaendran Kandiah

Ming-Chyi Pai

Vorapun Senanarong

Abstract

Several studies have demonstrated clinical benefits of sustained cholinesterase inhibition with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique...

Subject

Rivastigmine

Acetylcholinesterase

Butyrylcholinesterase

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