Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with <sup>225</sup>Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding

Kratochwil, Clemens; Bruchertseifer, Frank; Rathke, Hendrik; Bronzel, Marcus; Apostolidis, Christos; Weichert, Wilko; Haberkorn, Uwe; L. Giesel, Frederik; Morgenstern, Aliyah

doi:10.2967/jnumed.117.191395

Public

Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding

Published in Journal of Nuclear Medicine • Apr 13, 2017

Authors:

Clemens Kratochwil

Frank Bruchertseifer

Hendrik Rathke

Abstract

The aim of this study was to develop a treatment protocol for 225Ac-PSMA-617 α-radiation therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with prostate-specific membrane antigen (PSMA)–positive tumor phenotype. Methods: A dosimetry estimate was calculated on the ba...

Subject

Prostate cancer

Dosimetry

Medicine

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