Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

R. Chalmers, Zachary; Connelly, Caitlin; Fabrizio, David; M. Gay, Laurie; M. Ali, Siraj; Ennis, Riley; B. Schrock, Alexa; Campbell, Brittany; Shlien, Adam; Chmielecki, Juliann; W. Huang, Franklin; He, Yuting; Sun, James; Tabori, Uri; Kennedy, Mark; S. Lieber, Daniel; Roels, Steven; White, Jared; A. Otto, Geoffrey; S. Ross, Jeffrey; A. Garraway, Levi; A. Miller, Vincent; J. Stephens, P.; M. Frampton, Garrett

doi:10.1186/s13073-017-0424-2

Public

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Published in Genome Medicine • Apr 13, 2017

Authors:

Zachary R. Chalmers

Caitlin Connelly

David Fabrizio

Abstract

BACKGROUND: High tumor mutational burden (TMB) is an emerging biomarker of sensitivity to immune checkpoint inhibitors and has been shown to be more significantly associated with response to PD-1 and PD-L1 blockade immunotherapy than PD-1 or PD-L1 expression, as measured by immunohistochemistry (IHC...

Subject

Microsatellite instability

Exome sequencing

Germline

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