Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Schmittnaegel, Martina; Rigamonti, Nicolò; Kadioglu, Ece; Cassará, Antonino; Wyser Rmili, Céline; Kiialainen, Anna; Kienast, Yvonne; Mueller, H.P.; Ooi, Chia-Huey; Laoui, Damya; De Palma, Michele

doi:10.1126/scitranslmed.aak9670

Public

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Published in Science Translational Medicine • Apr 12, 2017

Authors:

Martina Schmittnaegel

Nicolò Rigamonti

Ece Kadioglu

Abstract

cytotoxic T lymphocytes (CTLs). Whereas the antitumoral activity of A2V was, at least partly, CTL-dependent, perivascular T cells concurrently up-regulated the expression of the immune checkpoint ligand programmed cell death ligand 1 (PD-L1) in tumor endothelial cells. IFNγ neutralization blunted th...

Subject

Blockade

Immune checkpoint

Angiopoietin 2

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