PK-guided personalized prophylaxis with Nuwiq<sup>®</sup> (human-cl rhFVIII) in adults with severe haemophilia A.

T, Lissitchkov; L, Rusen; P, Georgiev; J, Windyga; R, Klamroth; L, Gercheva; L, Nemes; A, Tiede; J, Bichler; S, Knaub; L, Belyanskaya; O, Walter; KJ, Pasi

doi:10.1111/hae.13251

Public

PK-guided personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in adults with severe haemophilia A.

Shared by NobleBlocks on Apr 27, 2017 • 12:00 AM UTC

Authors:

Lissitchkov T

Rusen L

Georgiev P

Abstract

Introduction Nuwiq® (human-cl rhFVIII) is a 4th generation recombinant human FVIII, without chemical modification or protein fusion, produced in a human cell-line.Aims/methods This study (NuPreviq) was a prospective, open-label, multicentre, phase IIIb study of the efficacy and safety of personalize...

Subject

Pharmacokinetics

Haemophilia A

Human-cl Rhfviii

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