Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

O. Kamphorst, Alice; N. Pillai, Rathi; Yang, Shu; H. Nasti, Tahseen; Akondy, Rama; Wieland, Andreas; Sica, Gabriel; Yu, Ke; Koenig, Lydia; Patel, Nikita; Behera, Madhusmita; Wu, Hong; McCausland, Megan; Chen, Zhengjia; Zhang, Chao; R. Khuri, Fadlo; K. Owonikoko, Taofeek; Ahmed, Rafi; S. Ramalingam, Suresh

doi:10.1073/pnas.1705327114

Public

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

Published in Proceedings of the National Academy of Sciences • Apr 26, 2017

Authors:

Alice O. Kamphorst

Rathi N. Pillai

Shu Yang

Abstract

Significance Therapies that harness the immune system have recently been approved for cancer treatment. Identification of biomarkers to monitor or predict patients’ responses to immunotherapies would help guide treatment decisions. Herein we analyzed changes in peripheral blood T cells from lung can...

Subject

CD8

CD28

Lung cancer

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