Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

E. Justice, Anne; W. Winkler, Thomas; F. Feitosa, Mary; Graff, Misa; Fisher, Virginia; L. Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; S. Ngwa, Julius; S. Ahluwalia, Tarunveer; Y. Chu, Audrey; L. Heard‐Costa, Nancy; Lim, Elise; Perez, Jeremiah; D. Eicher, John; Kutalik, Zoltán; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Tamuno, Alfred; Amin, Najaf; F. Bielak, Lawrence; Bonnefond, Amélie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Neşe; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao; E. Huffman, Jennifer; Jackson, Anne; Marie Justesen, Johanne; Kanoni, Stavroula; Kinnunen, Leena; E. Kleber, Marcus; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian’an; Lyytikäinen, Leo‐Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; P. S. Middelberg, Rita; Müller‐Nurasyid, Martina; Navarro, Pau; Përusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; V. Smith, Albert; A. Smith, Jennifer; Stančáková, Alena; J. Strawbridge, Rona; M. Stringham, Heather; Ju Sung, Yun; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; W. van der Laan, Sander; J. van der Most, Peter; V. van Vliet‐Ostaptchouk, Jana; Vedantam, Sailaja; Verweij, Niek; M. Vink, Jacqueline; Vitart, Véronique; Wu, Ying; Yengo, Loïc; Zhang, Weihua; Zhao, Wei; E. Zimmermann, Martina; Zubair, Niha; R. Abecasis, Gonçalo; S. Adair, Linda; Afaq, Saima; Afzal, Uzma; J. L. Bakker, Stephan; M. Bartz, Traci; Beilby, John; N. Bergman, Richard; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; L. Bonnycastle, Lori; P. Böttinger, Erwin; Braga, Daniele; M. Buckley, Brendan; Buyske, Steven; Campbell, Harry; C. Chambers, John; S. Collins, Francis; E. Curran, Joanne; J. de Borst, Gert; J. M. de Craen, Anton; J. C. de Geus, Eco; Dedoussis, George; E. Delgado, Graciela; M. den Ruijter, Hester; Eiríksdóttir, Guðný; L. Eriksson, Anna; Esko, Tõnu; D. Faul, Jessica; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; B. Grammer, Tanja; Grarup, Niels; Haitjema, Saskia; Hallmans, Göran; Hamsten, Anders; Hansen, Torben; B. Harris, Tamara; A. Hartman, Catharina; Hassinen, Maija; D. Hastie, Nicholas; C. Heath, Andrew; Hernández, Dena; A. Hindorff, Lucia; J. Hocking, Lynne; Hollensted, Mette; L. Holmen, Oddgeir; Homuth, Georg; Jan Hottenga, Jouke; Huang, Jie; Hung, Joseph; Hutri‐Kähönen, Nina; Ingelsson, Erik; L. James, Alan; Jansson, John-Olov; Järvelin, Marjo‐Riitta; A. Jhun, Min; E. Jørgensen, Marit; Juonala, Markus; Kähönen, Mika; K. Karlsson, Magnus; A. Koistinen, Heikki; Kolčić, Ivana; Kolovou, Genovefa; Kooperberg, Charles; K. Krämer, Bernhard; Kuusisto, Johanna; Kvaløy, Kirsti; A. Lakka, Timo; Langenberg, Claudia; J. Launer, Lenore; Leander, Karin; Lee, Sang; Lind, Lars; M. Lindgren, Cecilia; Linneberg, Allan; Lobbens, Stéphane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; H. Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; A. F. Madden, Pamela; Männikkö, Reija; Marques‐Vidal, Pedro; G. Martin, Nicholas; A. McKenzie, Colin; McKnight, Barbara; Mellström, Dan; Menni, Cristina; W. Montgomery, Grant; Musk, AW; Narisu, Narisu; Nauck, Matthias; M. Nolte, Ilja; J. Oldehinkel, Albertine; Olden, Matthias; K. Ong, Ken; Padmanabhan, Sandosh; A. Peyser, Patricia; Pisinger, Charlotta; J. Porteous, David; T. Raitakari, Olli; Rankinen, Tuomo; C. Rao, D.; J. Rasmussen‐Torvik, Laura; Rawal, Rajesh; Rice, Treva; M. Ridker, Paul; M. Rose, Lynda; A. Bien, Stephanie; Rudan, Igor; Sanna, Serena; A. Sarzynski, Mark; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; A. Scott, Robert; Sennblad, Bengt; A. Siemelink, Marten; Silbernagel, Günther; Eline Slagboom, P.; Snieder, Harold; A. Staessen, Jan; J. Stott, David; A. Swertz, Morris; J. Swift, Amy; D. Taylor, Kent; O. Tayo, Bamidele; Thorand, Barbara; Thuillier, Dorothée; Tuomilehto, Jaakko; G. Uitterlinden, André; Vandenput, Liesbeth; Vohl, Marie‐Claude; Völzke, Henry; M. Vonk, Judith; Waeber, Gérard; Waldenberger, Mélanie; G. J. Westendorp, Rudi; H. Wild, Sarah; Willemsen, Gonneke; H. R. Wolffenbuttel, Bruce; Wong, Andrew; F. Wright, Alan; Zhao, Wei; Carola Zillikens, M.; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; A. Böger, Carsten; I. Boomsma, Dorret; Bouchard, Claude; Bruinenberg, Marcel; I. Chasman, Daniel; Chen, Yii-DerIda; S. Chines, Peter; S. Cooper, Richard; Cucca, Francesco; Cusi, Daniele; dé Fairé, Ulf; Ferrucci, Luigi; W. Franks, Paul; Froguel, Philippe; Gordon‐Larsen, Penny; J. Grabe, Hans; Guðnason, Vilmundur; A. Haiman, Christopher; Hayward, Caroline; Hveem, Kristian; D. Johnson, Andrew; Wouter Jukema, J.; L. R. Kardia, Sharon; Kivimäki, Mika; S. Kooner, Jaspal; Kuh, Diana; Laakso, Markku; Lehtimäki, Terho; Le Marchand, Loı̈c; März, Winfried; I. McCarthy, Mark; Metspalu, Andres; P. Morris, Andrew; Ohlsson, Claes; J. Palmer, Lyle; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polašek, Ozren; M. Psaty, Bruce; Qi, Lu; Rauramaa, Rainer; H. Smith, Blair; I. A. Sørensen, Thorkild; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Péter; J. Wareham, Nicholas; R. Weir, David; B. Whitfield, John; F. Wilson, James; Tyrrell, Jessica; M. Frayling, Timothy; Barroso, Inês; Boehnke, Michael; Deloukas, Panagiotis; S. Fox, Caroline; N. Hirschhorn, Joel; J. Hunter, David; D. Spector, Tim; P. Strachan, David; M. van Duijn, Cornelia; M. Heid, Iris; L. Mohlke, Karen; Marchini, Jonathan; J. F. Loos, Ruth; O. Kilpeläinen, Tuomas; Liu, Ching‐Ti; B. Borecki, Ingrid; E. North, Kari; Adrienne Cupples, L.

doi:10.1038/ncomms14977

Public

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Published in Nature Communications • Apr 26, 2017

Authors:

Anne E. Justice

Thomas W. Winkler

Mary F. Feitosa

Abstract

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% Europea...

Subject

Genome-wide association study

Genetics

Obesity

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!