A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

Li, Qiuhong; P. Hutchins, Andrew; Chen, Yong; Li, Shengbiao; Shan, Yongli; Liao, Baojian; Zheng, Dejin; Shi, Xi; Li, Yinxiong; Chan, Wai‐Yee; Pan, Guangjin; Wei, Shicheng; Shu, Xiaodong; Pei, Duanqing

doi:10.1038/ncomms15166

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A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

Published in Nature Communications • May 3, 2017

Authors:

Qiuhong Li

Andrew P. Hutchins

Yong Chen

Abstract

Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to hepatic lineage undergoes a sequential EMT-MET with an obligatory intermediate mesenchymal phase. Gene expression analysis reveals that Acti...

Subject

SNAI1

Cell biology

Embryonic stem cell

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