The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression

V. Brown, Robert; Wang, Ting; Reddy Chappeta, Venkateshwar; Wu, Guanhui; Onel, Buket; Chawla, Reena; Quijada, Hector; M. Camp, Sara; T. Chiang, Eddie; R. Lassiter, Quinea; Lee, Carmen; Phanse, Shivani; A. Turnidge, Megan; Zhao, Ping; G. N. Garcia, Joe; Gokhale, Vijay; Yang, Danzhou; H. Hurley, Laurence

doi:10.1021/jacs.6b10028

Public

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression

Published in Journal of the American Chemical Society • May 4, 2017

Authors:

Robert V. Brown

Ting Wang

Venkateshwar Reddy Chappeta

Abstract

The platelet-derived growth factor receptor β (PDGFR-β) signaling pathway is a validated and important target for the treatment of certain malignant and nonmalignant pathologies. We previously identified a G-quadruplex-forming nuclease hypersensitive element (NHE) in the human PDGFR-β promoter that ...

Subject

Point mutation

Chemistry

G-quadruplex

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