Transcranial Functional Ultrasound Imaging in Freely Moving Awake Mice and Anesthetized Young Rats without Contrast Agent

Tiran, Elodie; Ferrier, Jérémy; Deffieux, Thomas; Gennisson, Jean‐Luc; Pezet, Sophie; Lenkei, Zsolt; Tanter, Mickaël

doi:10.1016/j.ultrasmedbio.2017.03.011

Public

Transcranial Functional Ultrasound Imaging in Freely Moving Awake Mice and Anesthetized Young Rats without Contrast Agent

Published in Ultrasound in Medicine & Biology • May 4, 2017

Authors:

Elodie Tiran

Jérémy Ferrier

Thomas Deffieux

Abstract

Functional ultrasound (fUS) imaging by ultrasensitive Doppler detection of blood volume was previously reported to measure adult rat brain activation and functional connectivity with unmatched spatiotemporal sampling (100 μm, 1 ms), but skull-induced attenuation of ultrasonic waves imposed skull sur...

Subject

Transcranial Doppler

Medicine

Skull

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