MiR-34a Promotes Apoptosis and Inhibits Autophagy by Targeting HMGB1 in Acute Myeloid Leukemia Cells

Liu, Liru; Ren, Weihua; Chen, Kuisheng

doi:10.1159/000475277

Public

MiR-34a Promotes Apoptosis and Inhibits Autophagy by Targeting HMGB1 in Acute Myeloid Leukemia Cells

Published in Cellular Physiology and Biochemistry • Jan 1, 2017

Authors:

Liru Liu

Weihua Ren

Kuisheng Chen

Abstract

BACKGROUND: MiR-34a is identified as a tumor suppressor gene and involved in acute myeloid leukemia (AML) development. However, the regulatory mechanism of miR-34a in AML is unclear. METHODS: The expression of miR-34a and HMGB1 in HL-60, THP-1 and HS-5 cells were detected by qRT-PCR and western blot...

Subject

Autophagy

Apoptosis

Myeloid leukemia

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