MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

Shigemoto-Kuroda, Taeko; Youn Oh, Joo; Ki Kim, Dong; Jeong Jeong, Hyun; Yeon Park, Se; Ju Lee, Hyun; Woo Park, Jong; Wan Kim, Tae; Yeon An, Su; J. Prockop, Darwin; Hwa Lee, Ryang

doi:10.1016/j.stemcr.2017.04.008

Public

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

Published in Stem Cell Reports • May 1, 2017

Authors:

Taeko Shigemoto-Kuroda

Joo Youn Oh

Dong Ki Kim

Abstract

Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoret...

Subject

Mesenchymal stem cell

Autoimmunity

Immunology

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