Therapeutic Development of Mesenchymal Stem Cells or Their Extracellular Vesicles to Inhibit Autoimmune-Mediated Inflammatory Processes in Systemic Lupus Erythematosus

Sharma, Juhi; Hampton, J.; R. Valiente, Giancarlo; Tsuzuki Wada, Takuma; Steigelman, H; C. Young, Matthew; R. Spurbeck, Rachel; D. Blazek, Alisa; Bösh, Steffi; N. Jarjour, Wael; A. Young, Nicholas

doi:10.3389/fimmu.2017.00526

Public

Therapeutic Development of Mesenchymal Stem Cells or Their Extracellular Vesicles to Inhibit Autoimmune-Mediated Inflammatory Processes in Systemic Lupus Erythematosus

Published in Frontiers in Immunology • May 10, 2017

Authors:

Juhi Sharma

J. Hampton

Giancarlo R. Valiente

Abstract

Since being discovered over half a century ago, mesenchymal stem cells (MSCs) have been investigated extensively to characterize their cellular and physiological influences. MSCs have been shown to possess immunosuppressive capacity through inhibiting lymphocyte activation/proliferation and proinfla...

Subject

Mesenchymal stem cell

Immunology

Proinflammatory cytokine

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