High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β <sub>2</sub> -Adrenergic Receptor/G <sub>i</sub> –Dependent Manner

Paur, Helen; Wright, Peter; B. Sikkel, Markus; H. Tranter, Matthew; Mansfield, Catherine; O’Gara, Peter; J. Stuckey, Daniel; O. Nikolaev, Viacheslav; Diakonov, Ivan; Pannell, Laura; Gong, Hai‐Bin; Sun, Hong; S. Peters, Nicholas; Petrou, Mario; Zheng, Zhaolun; Gorelik, Julia; R. Lyon, Alexander; E. Harding, Siân

doi:10.1161/circulationaha.112.111591

Public

High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β 2 -Adrenergic Receptor/G i –Dependent Manner

Published in Circulation • Jun 27, 2012

Authors:

Helen Paur

Peter Wright

Markus B. Sikkel

Abstract

BACKGROUND: Takotsubo cardiomyopathy is an acute heart failure syndrome characterized by myocardial hypocontractility from the mid left ventricle to the apex. It is precipitated by extreme stress and can be triggered by intravenous catecholamine administration, particularly epinephrine. Despite its ...

Subject

Medicine

Epinephrine

Adrenergic receptor

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