Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y<sub>1</sub> Receptor Downregulation.

Y, Shinozaki; K, Shibata; K, Yoshida; E, Shigetomi; C, Gachet; K, Ikenaka; KF, Tanaka; S, Koizumi

doi:10.1016/j.celrep.2017.04.047

Public

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.

Shared by NobleBlocks on May 1, 2017 • 12:00 AM UTC

Authors:

Shinozaki Y

Shibata K

Yoshida K

Abstract

Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective phenotype via downregulation of the P2Y1 purinergic ...

Subject

Cytokines

ATP

Traumatic brain injury

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