Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma

Prat, Aleix; Navarro, Alejandro; Paré, Laia; Reguart, Noemı́; Galván, Patricia; Pascual, Tomás; Martínez‐Martí, Alex; Nucíforo, Paolo; Comerma, Laura; Alós, Llúcia; Pardo, Núria; Cedrés, S.; Fan, Cheng; S. Parker, Joel; Gaba, Lydia; Victoria, Iván; Viñolas, Núria; Vivancos, Ana; Arance, Ana; Felip, Enriqueta

doi:10.1158/0008-5472.can-16-3556

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Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma

Published in Cancer Research • May 9, 2017

Authors:

Aleix Prat

Alejandro Navarro

Laia Paré

Abstract

Abstract Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but most patients exhibit partial or complete resistance to treatment for reasons that are unclear. In this study, we evaluated tumor specimens from 65 patients with melanoma...

Subject

Nivolumab

Head and neck squamous-cell carcinoma

Pembrolizumab

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