Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

Pires Hartwig, Fernando; Davey Smith, George; Bowden, Jack

doi:10.1093/ije/dyx102

Public

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

Published in International Journal of Epidemiology • May 22, 2017

Authors:

Fernando Pires Hartwig

George Davey Smith

Jack Bowden

Abstract

Background: Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR usi...

Subject

Mendelian randomization

Instrumental variable

Pleiotropy

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