The DNA sequence of human chromosome 21

Hattori, Masahira; Fujiyama, Asao; D. Taylor, Todd; Watanabe, Hitoshi; Yada, Tetsushi; Park, H.-S.; Toyoda, Atsushi; Ishii, Kazuo; Totoki, Yasushi; Choi, Dong‐Kug; Soeda, E; Ohki, Masafumi; Takagi, Toshiyuki; Sakaki, Yoshiyuki; Taudien, Stefan; Blechschmidt, Karin; Polley, Andreas; Menzel, Uwe; Delabar, J.M.; Kumpf, Kai; Lehmann, R.; Patterson, David; Reichwald, Kathrin; Rump, Andreas; Schillhabel, M.; Schudy, Andreas; Zimmermann, Wolfgang; Rosenthal, André; Kudoh, Jun; Shibuya, Kazunori; Kawasaki, Kazuhiko; Asakawa, Shuichi; Shintani, Ai; Sasaki, Takashi; Nagamine, Kentaro; Mitsuyama, Susumu; E. Antonarakis, Stylianos; Minoshima, Satoshi; Shimizu, Nobutaka; Nordsiek, Gabriele; Hornischer, Klaus; Brandt, P.; Scharfe, Maren; Schön, Oliver; Desario, A.; Reichelt, Julia; Kauer, Gerhard; Blöcker, Helmut; Ramser, Juliane; Beck, Amy; Klages, Sven; Hennig, Steffen; Rießelmann, L.; Dagand, Emilie; Haaf, Thomas; Wehrmeyer, S.; Borzym, Katja; Gardiner, Katheleen; Nižetić, Dean; Francis, Fiona; Lehrach, Hans; Reinhardt, Richard; Yaspo, Marie‐Laure

doi:10.1038/35012518

Public

The DNA sequence of human chromosome 21

Published in Nature • May 18, 2000

Authors:

Masahira Hattori

Asao Fujiyama

Todd D. Taylor

Abstract

Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions for common complex disord...

Subject

Genetics

Pseudogene

Biology

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