Cisplatin-resistant lung cancer cell&amp;ndash;derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100&amp;ndash;5p-dependent manner

Qin, Xiaobing; Yu, Shaorong; Zhou, Leilei; Shi, Meiqi; Hu, Yong; Xu, Xiaoyue; Shen, Bo; Liu, Siwen; Yan, Dali; Feng, Jifeng

doi:10.2147/ijn.s131516

Public

Cisplatin-resistant lung cancer cell–derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100–5p-dependent manner

Published in International Journal of Nanomedicine • May 1, 2017

Authors:

Xiaobing Qin

Shaorong Yu

Leilei Zhou

Abstract

Exosomes derived from lung cancer cells confer cisplatin (DDP) resistance to other cancer cells. However, the underlying mechanism is still unknown. A549 resistance to DDP (A549/DDP) was established. Microarray was used to analyze microRNA (miRNA) expression profiles of A549 cells, A549/DDP cells, A...

Subject

Microvesicles

A549 cell

microRNA

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