Resistance to malaria through structural variation of red blood cell invasion receptors.

EM, Leffler; G, Band; GBJ, Busby; K, Kivinen; QS, Le; GM, Clarke; KA, Bojang; DJ, Conway; M, Jallow; F, Sisay-Joof; EC, Bougouma; VD, Mangano; D, Modiano; SB, Sirima; E, Achidi; TO, Apinjoh; K, Marsh; CM, Ndila; N, Peshu; TN, Williams; C, Drakeley; A, Manjurano; H, Reyburn; E, Riley; D, Kachala; M, Molyneux; V, Nyirongo; T, Taylor; N, Thornton; L, Tilley; S, Grimsley; E, Drury; J, Stalker; V, Cornelius; C, Hubbart; AE, Jeffreys; K, Rowlands; KA, Rockett; CCA, Spencer; DP, Kwiatkowski

doi:10.1126/science.aam6393

Public

Resistance to malaria through structural variation of red blood cell invasion receptors.

Shared by NobleBlocks on May 18, 2017 • 12:00 AM UTC

Authors:

Leffler EM

Band G

Busby GBJ

Abstract

The malaria parasite Plasmodium falciparum invades human red blood cells by a series of interactions between host and parasite surface proteins. By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy-num...

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