Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

S. Taylor, Hugh; C. Giudice, Linda; A. Lessey, Bruce; Simões Abrão, Maurício; Kotarski, Jan; F. Archer, David; P. Diamond, Michael; S. Surrey, Eric; P. Johnson, Neil; B. Watts, Nelson; C. Gallagher, John; A. Simon, James; R. Carr, Bruce; Paul Dmowski, W.; Leyland, Nicholas; Rowan, J.P.; Rachel Duan, W.; Ng, Juki; Schwefel, Brittany; W. Thomas, James; I. Jain, Rita; Chwalisż, Kristof

doi:10.1056/nejmoa1700089

Public

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

Published in New England Journal of Medicine • May 19, 2017

Authors:

Hugh S. Taylor

Linda C. Giudice

Bruce A. Lessey

Abstract

BACKGROUND: Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Elagolix, an oral, nonpeptide, gonadotropin-releasing hormone (GnRH) antagonist, produced partial to nearly full estrogen suppression in previous studies. METHODS: We performed two similar,...

Subject

Medicine

Endometriosis

Antagonist

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