Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Milne, Paul; Bigley, Venetia; M. Bacon, Chris; Néel, A.; McGovern, Naomi; Bomken, Simon; Haniffa, Muzlifah; L. Diamond, Eli; H. Durham, Benjamin; Visser, Johannes; Hunt, David; Gunawardena, Harsha; Macheta, Mac; L. McClain, Kenneth; E. Allen, Carl; Abdel‐Wahab, Omar; Collin, Matthew

doi:10.1182/blood-2016-12-757823

Public

Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Published in Blood • May 16, 2017

Authors:

Paul Milne

Venetia Bigley

Chris M. Bacon

Abstract

DCs, made foamy macrophages easily in vitro with macrophage colony-stimulating factor and human serum. These studies are consistent with a hematopoietic origin and >1 immediate cellular precursor in both LCH and ECD.

Subject

Erdheim–Chester disease

Langerhans cell histiocytosis

Histiocytosis

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