FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats

Akiba, Yasutada; Maruta, Koji; Narimatsu, Kazuyuki; Said, Hyder; Kaji, Izumi; Kuri, Ayaka; Iwamoto, Ken‐ichi; Kuwahara, Atsukazu; D. Kaunitz, Jonathan

doi:10.1152/ajpgi.00041.2017

Public

FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats

Published in American Journal of Physiology-Gastrointestinal and Liver Physiology • May 19, 2017

Authors:

Yasutada Akiba

Koji Maruta

Kazuyuki Narimatsu

Abstract

Serotonin (5-HT), predominantly synthesized and released by enterochromaffin cells, is implicated in gastrointestinal symptoms such as emesis, abdominal pain, and diarrhea. Because luminal short-chain fatty acids (SCFAs) release 5-HT from enterochromaffin cells, which express the SCFA receptor free ...

Subject

Pharmacology

Chemistry

5-HT receptor

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