Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

Yang, Chun; Ren, Qian; Qu, Youge; Zhang, Ji‐chun; Ma, Min; Dong, Chao; Hashimoto, Kenji

doi:10.1016/j.biopsych.2017.05.016

Public

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

Published in Biological Psychiatry • May 31, 2017

Authors:

Chun Yang

Qian Ren

Youge Qu

Abstract

BACKGROUND: The role of the mechanistic target of rapamycin (mTOR) signaling in the antidepressant effects of ketamine is controversial. In addition to mTOR, extracellular signal-regulated kinase (ERK) is a key signaling molecule in prominent pathways that regulate protein synthesis. (R)-Ketamine ha...

Subject

Antidepressant

PI3K/AKT/mTOR pathway

MAPK/ERK pathway

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