Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Morland, Cecilie; A. Andersson, Krister; P. Haugen, Øyvind; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Egge Rinholm, Johanne; Palibrk, Vuk; Holm Diget, Elisabeth; Kennedy, Lauritz; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja; Offermanns, Stefan; Vervaeke, Koen; Bjørås, Magnar; Wisløff, Ulrik; Storm‐Mathisen, Jon; H. Bergersen, Linda

doi:10.1038/ncomms15557

Public

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Published in Nature Communications • May 23, 2017

Authors:

Cecilie Morland

Krister A. Andersson

Øyvind P. Haugen

Abstract

Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-l...

Subject

Pericyte

Angiogenesis

Skeletal muscle

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