Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections

Vijayan, Kamalakannan; Priyadarshini Karthigeyan, Krithika; P. Tripathi, Srikanth; Elizabeth Hanna, Luke

doi:10.3389/fimmu.2017.00580

Public

Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections

Published in Frontiers in Immunology • May 23, 2017

Authors:

Kamalakannan Vijayan

Krithika Priyadarshini Karthigeyan

Srikanth P. Tripathi

Abstract

The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity that leads ultimately to death. HIV infection in humans is caused by two related yet distinct viruses: HIV-1 and HIV-2. HI...

Subject

Human immunodeficiency virus (HIV)

Immunity

Immunology

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