Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

T. Le, Dung; N. Durham, Jennifer; N. Smith, Kellie; Wang, Hao; R. Bartlett, Bjarne; K. Aulakh, Laveet; Lu, Steve; Kemberling, Holly; Wilt, Cara; Luber, Brandon; Wong, Fay; S. Azad, Nilofer; A. Rucki, Agnieszka; Laheru, Dan; C. Donehower, Ross; Zaheer, Atif; A. Fisher, George; S. Crocenzi, Todd; J. Lee, James; F. Greten, Tim; G. Duffy, Austin; K. Ciombor, Kristen; Eyring, Aleksandra; H. Lam, Bao; K. Joe, Andrew; Peter Kang, Soonmo; Holdhoff, Matthias; Danilova, Ludmila; Cope, Leslie; F. Meyer, Christian; Zhou, Shibin; M. Goldberg, Richard; K. Armstrong, Deborah; M. Bever, Katherine; N. Fader, Amanda; M. Taube, Janis; Housseau, Franck; Spetzler, David; Xiao, Nianqing; M. Pardoll, Drew; Papadopoulos, Nickolas; W. Kinzler, Kenneth; R. Eshleman, James; Vogelstein, Bert; A. Anders, Robert; A. Díaz, Luis

doi:10.1126/science.aan6733

Public

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Published in Science • Jul 27, 2017

Authors:

Dung T. Le

Jennifer N. Durham

Kellie N. Smith

Abstract

The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with mismatch repair deficiency were sensitive to immune checkpoint blockade with antibodies to programmed death rece...

Subject

Blockade

Solid tumor

Medicine

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