Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1.

Ndam N, Tuikue; A, Moussiliou; T, Lavstsen; C, Kamaliddin; ATR, Jensen; A, Mama; R, Tahar; CW, Wang; JS, Jespersen; JM, Alao; B, Gamain; TG, Theander; P, Deloron

doi:10.1093/infdis/jix230

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Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1.

Shared by NobleBlocks on Jun 1, 2017 • 12:00 AM UTC

Authors:

Tuikue Ndam N

Moussiliou A

Lavstsen T

Abstract

Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1 (...

Subject

Plasmodium falciparum

Cerebral malaria

ICAM-1

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