Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1

Tuikue Ndam, Nicaise; Moussiliou, Azizath; Lavstsen, Thomas; Kamaliddin, Claire; T. R. Jensen, Anja; Mama, Atikatou; Tahar, Rachida; W. Wang, Christian; S. Jespersen, Jakob; Alao, Jules; Gamain, Benoît; G. Theander, Thor; Deloron, Philippe

doi:10.1093/infdis/jix230

Public

Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1

Published in The Journal of Infectious Diseases • May 10, 2017

Authors:

Nicaise Tuikue Ndam

Azizath Moussiliou

Thomas Lavstsen

Abstract

Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1 ...

Subject

Endothelial protein C receptor

Malaria

Cerebral Malaria

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