Risks of Breast, Ovarian, and Contralateral Breast Cancer for <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers

Kuchenbaecker, Karoline; L. Hopper, John; R. Barnes, Daniel; Phillips, Kelly‐Anne; M. Mooij, Thea; Roos-Blom, Marie-José; Jervis, Sarah; E. van Leeuwen, Flora; L. Milne, Roger; Andrieu, Nadine; E. Goldgar, David; Beth Terry, Mary; A. Rookus, Matti; F. Easton, Douglas; C. Antoniou, Antonis; McGuffog, Lesley; Gareth Evans, D.; Barrowdale, Daniel; Frost, Debra; Adlard, Julian; Ong, Kai-Ren; Izatt, Louise; Tischkowitz, Marc; A. Eeles, Rosalind; Davidson, Rosemarie; Hodgson, Shirley; Ellis, Steve; Noguès, Catherine; Lasset, Christine; Stoppa‐Lyonnet, Dominique; Fricker, Jean‐Pierre; Faivre, Laurence; Berthet, Pascaline; J. Hooning, Maartje; E. van der Kolk, Lizet; M. Kets, Carolien; A. Adank, Muriel; M. John, Esther; K. Chung, Wendy; L. Andrulis, Irene; C. Southey, Melissa; B. Daly, Mary; S. Buys, Saundra; Osório, Ana; Engel, Christoph; Kast, Karin; K. Schmutzler, Rita; Caldés, Trinidad; Jakubowska, Anna; Simard, Jacques; Friedländer, Michael; McLachlan, Sue‐Anne; Macháčková, Eva; Foretová, Lenka; Y. Tan, Yen; F. Singer, Christian; Oláh, Edith; Gerdes, Anne‐Marie; Arver, Brita; Olsson, Håkan

doi:10.1001/jama.2017.7112

Public

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Published in JAMA • Jun 20, 2017

Authors:

Karoline Kuchenbaecker

John L. Hopper

Daniel R. Barnes

Abstract

Importance: The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. Objectives: To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer histo...

Subject

Medicine

Breast cancer

Oncology

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