The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

Koppula, Pranavi; Zhang, Yilei; Shi, Jiejun; Li, Wei; Gan, Boyi

doi:10.1074/jbc.m117.798405

Public

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

Published in Journal of Biological Chemistry • Jun 20, 2017

Authors:

Pranavi Koppula

Yilei Zhang

Jiejun Shi

Abstract

Cancer cells with specific genetic alterations may be highly dependent on certain nutrients for survival, which can inform therapeutic strategies to target these cancer-specific metabolic vulnerabilities. The glutamate/cystine antiporter solute carrier family 7 member 11 (SLC7A11, also called xCT) i...

Subject

Cancer cell

Glutamate receptor

Biology

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