IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

Ayers, Mark; Lunceford, Jared; Nebozhyn, Michael; Murphy, Erin; Loboda, Andrey; R. Kaufman, David; Albright, Andrew; D. Cheng, Jonathan; Kang, Shijun; Shankaran, Veena; A. Piha‐Paul, Sarina; H. Yearley, Jennifer; Y. Seiwert, Tanguy; Ribas, Antoni; K. McClanahan, Terrill

doi:10.1172/jci91190

Public

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

Published in Journal of Clinical Investigation • Jun 25, 2017

Authors:

Mark Ayers

Jared Lunceford

Michael Nebozhyn

Abstract

Programmed death-1-directed (PD-1-directed) immune checkpoint blockade results in durable antitumor activity in many advanced malignancies. Recent studies suggest that IFN-γ is a critical driver of programmed death ligand-1 (PD-L1) expression in cancer and host cells, and baseline intratumoral T cel...

Subject

Pembrolizumab

Immune checkpoint

Medicine

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