CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery

Wang, Hongxia; Li, Mingqiang; M. Lee, Ciaran; Chakraborty, Syandan; Kim, Hae‐Won; Bao, Gang; W. Leong, Kam

doi:10.1021/acs.chemrev.6b00799

Public

CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery

Published in Chemical Reviews • Jun 22, 2017

Authors:

Hongxia Wang

Mingqiang Li

Ciaran M. Lee

Abstract

Genome editing offers promising solutions to genetic disorders by editing DNA sequences or modulating gene expression. The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) technology can be used to edit single or multiple genes in a wide variety o...

Subject

CRISPR

Genome editing

Cas9

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