Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Jusakul, Apinya; Cutcutache, Ioana; Han Yong, Chern; Quan Lim, Jing; Ni Huang, Mi; Padmanabhan, Nisha; Nellore, Vishwa; Kongpetch, Sarinya; Wei Tian Ng, Alvin; Moy Ng, Ley; Pin Choo, Su; Swe Myint, Swe; Thanan, Raynoo; Nagarajan, Sanjanaa; Khong Lim, Weng; Chuan Young Ng, Cedric; Boot, Arnoud; Liu, Mo; Kiat Ong, Choon; Rajasegaran, Vikneswari; Lie, Stefanus; Soon Tiong Lim, Alvin; Hui Lim, Tse; Tan, Jing; Liang Loh, Jia; R. McPherson, John; Khuntikeo, Narong; Bhudhisawasdi, Vajaraphongsa; Yongvanit, Puangrat; Wongkham, Sopit; Totoki, Yasushi; Nakamura, Hiromi; Arai, Yasuhito; Yamasaki, Satoshi; K. H. Chow, Pierce; Yaw Fui Chung, Alexander; Lucien Ooi, London; Hon Lim, Kiat; Dima, Simona; G. Duda, Dan; Popescu, Irinel; Broët, Philippe; Hsieh, Sen‐Yung; Yu, Ming‐Chin; Scarpa, Aldo; Lai, Jiaming; Luo, Dixian; Lopes Carvalho, André; L. Vettore, André; Rhee, Hyungjin; Nyun Park, Young; B. Alexandrov, Ludmil; Gordân, Raluca; Rozen, Steve; Shibata, Tatsuhiro; Pairojkul, Chawalit; Tean Teh, Bin; Tan, Patrick

doi:10.1158/2159-8290.cd-17-0368

Public

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Published in Cancer Discovery • Jun 30, 2017

Authors:

Apinya Jusakul

Ioana Cutcutache

Chern Han Yong

Abstract

Abstract Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integra...

Subject

Biology

Genetics

Epigenomics

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