Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

José Lista, María; Prado Martins, Rodrigo; Billant, Olivier; Contesse, Marie‐Astrid; Findakly, Sarah; Pochard, Pierre; Daskalogianni, Chrysoula; Beauvineau, Claire; Guetta, Corinne; Jamin, Christophe; Teulade‐Fichou, Marie‐Paule; Fåhræus, Robin; Voisset, Cécile; Blondel, Marc

doi:10.1038/ncomms16043

Public

Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

Published in Nature Communications • Jul 7, 2017

Authors:

María José Lista

Rodrigo Prado Martins

Olivier Billant

Abstract

The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1, which is essential for viral genome maintenance but highly antigenic. EBV has seemingly evolved a system in which the mRNA sequence encoding the glycine-alanine repeats (GA...

Subject

Nucleolin

Biology

Messenger RNA

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