Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Costa-Gouveia, Joana; Pancani, Elisabetta; Jouny, Samuel; Machelart, Arnaud; Delorme, Vincent; Salzano, Giuseppina; Iantomasi, Raffaella; Piveteau, Catherine; J. Queval, Christophe; Song, Ok‐Ryul; Flipo, Marion; Déprez, Benoît; Saint‐André, Jean‐Paul; Hureaux, J.; Majlessi, Laleh; Willand, Nicolas; R. Baulard, Alain; Brodin, Priscille; Gref, Ruxandra

doi:10.1038/s41598-017-05453-3

Public

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Published in Scientific Reports • Jul 10, 2017

Authors:

Joana Costa-Gouveia

Elisabetta Pancani

Samuel Jouny

Abstract

Tuberculosis (TB) is a leading infectious cause of death worldwide. The use of ethionamide (ETH), a main second line anti-TB drug, is hampered by its severe side effects. Recently discovered "booster" molecules strongly increase the ETH efficacy, opening new perspectives to improve the current clini...

Subject

Ethionamide

Booster (rocketry)

Medicine

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