FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

Yang, Shucai; Liu, Yi; Li, Mingyue; S.H. Ng, Calvin; Yang, Shengli; Wang, Shanshan; Zou, Chang; Dong, Yujuan; Du, Jing; Long, Xiang; Liu, Lizhong; Y.P. Wan, Innes; Mok, Tony; J. Underwood, Malcolm; G. Chen, George

doi:10.1186/s12943-017-0700-1

Public

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

Published in Molecular Cancer • Jul 17, 2017

Authors:

Shucai Yang

Yi Liu

Mingyue Li

Abstract

BACKGROUND: The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC). METHODS: One hundred and six patients with histologically-confirmed NSCLC who underwent surgery...

Subject

Wnt signaling pathway

Biology

Metastasis

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