PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer

Flores, Orielyz; Santra, Santimukul; Kaittanis, Charalambos; Bassiouni, Rania; S. Khaled, Amr; R. Khaled, Annette; Grimm, Jan; Manuel Perez, J.

doi:10.7150/thno.18879

Public

PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer

Published in Theranostics • Jan 1, 2017

Authors:

Orielyz Flores

Santimukul Santra

Charalambos Kaittanis

Abstract

Herein, we report the use of a theranostic nanocarrier (Folate-HBPE(CT20p)) to deliver a therapeutic peptide to prostate cancer tumors that express PSMA (folate hydrolase 1). The therapeutic peptide (CT20p) targets and inhibits the chaperonin-containing TCP-1 (CCT) protein-folding complex, is select...

Subject

Nanocarriers

Prostate cancer

Cancer research

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